t(7;11) and trilineage myelodysplasia in acute myelomonocytic leukemia.

作者信息

Inaba T, Shimazaki C, Yoneyama S, Hirai H, Kikuta T, Sumikuma T, Sudo Y, Yamagata N, Ashihara E, Goto H, Fujita N, Nakagawa M

机构信息

Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

出版信息

Cancer Genet Cytogenet. 1996 Jan;86(1):72-5. doi: 10.1016/0165-4608(95)00160-3.

DOI:10.1016/0165-4608(95)00160-3

PMID:8616792

Abstract

A 48-year-old Japanese man was admitted to our hospital because of general fatigue, nasal bleeding, and petechiae on his extremities. He was diagnosed with acute myelomonocytic leukemia with trilineage myelodysplasia (T-MDS). Chromosomal analysis of bone marrow cells revealed t(7;11)(p15;p15), which has been rarely reported but known to be characteristic of Japanese patients. Although t(7;11)(p15;p15) has been reported mainly in acute myelogenous leukemia (AML), it can be occasionally found in so-called stem cell diseases such as chronic myelogenous leukemia or chronic myeloproliferative disorders. Therefore, t(7;11)(p15;p15) might affect trilineage progenitors or stem cells as well as myeloid lineage cells, subsequently resulting in AML with T-MDS, as in our case reported here.

摘要