Inaba T, Shimazaki C, Yoneyama S, Hirai H, Kikuta T, Sumikuma T, Sudo Y, Yamagata N, Ashihara E, Goto H, Fujita N, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Cancer Genet Cytogenet. 1996 Jan;86(1):72-5. doi: 10.1016/0165-4608(95)00160-3.
A 48-year-old Japanese man was admitted to our hospital because of general fatigue, nasal bleeding, and petechiae on his extremities. He was diagnosed with acute myelomonocytic leukemia with trilineage myelodysplasia (T-MDS). Chromosomal analysis of bone marrow cells revealed t(7;11)(p15;p15), which has been rarely reported but known to be characteristic of Japanese patients. Although t(7;11)(p15;p15) has been reported mainly in acute myelogenous leukemia (AML), it can be occasionally found in so-called stem cell diseases such as chronic myelogenous leukemia or chronic myeloproliferative disorders. Therefore, t(7;11)(p15;p15) might affect trilineage progenitors or stem cells as well as myeloid lineage cells, subsequently resulting in AML with T-MDS, as in our case reported here.
