Shibata T, Ochiai A, Gotoh M, Machinami R, Hirohashi S
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
Cancer Lett. 1996 Feb 6;99(2):147-53. doi: 10.1016/0304-3835(95)04047-1.
We examined the expression of cadherin-11, a type II cadherin, in normal human tissues, cell lines and gastric cancer surgical specimens. Cadherin-11 was expressed widely in adult tissues, except the liver. It was expressed in fibroblast, mesothelial cell lines, and in only two signet ring cell carcinomas out of 16 various cancer cell lines. Cadherin-11 expression was detected in both signet ring cell carcinoma cells and surrounding fibroblasts of surgical specimens by in situ hybridization. These results suggest that cadherin-11 may play a role in the formation of diffuse-type gastric cancer through cancer-stromal interactions.
我们检测了II型钙黏蛋白钙黏蛋白-11在正常人体组织、细胞系和胃癌手术标本中的表达情况。钙黏蛋白-11在除肝脏外的成人组织中广泛表达。它在成纤维细胞、间皮细胞系中表达，在16种不同癌细胞系中仅在两种印戒细胞癌中表达。通过原位杂交在手术标本的印戒细胞癌细胞和周围成纤维细胞中均检测到钙黏蛋白-11的表达。这些结果表明，钙黏蛋白-11可能通过癌-基质相互作用在弥漫型胃癌的形成中发挥作用。
