Armstrong W E, Gregory W A, Hatton G I
Brain Res Bull. 1977 Jan-Feb;2(1):7-14. doi: 10.1016/0361-9230(77)90019-3.
Subcutaneous injections of isotonic saline induced nucleolar proliferation in supraoptic neurons in animals sacrificed approximately 5 min postinjection. The magnitude of this proliferation was sustained 4 and 8 hr postinjection. Polyethylene glycol (PG) injections depleted blood volume 4 and 8 hr after the injection, but the percentage of SON cells with multiple nucleoli in these animals was not different from saline-injected controls. The anterior (SOa) portion of the SON in rats given 2% NaCl to drink instead of water for three days contained more cells with multiple nucleoli than controls. This effect was enhanced after five days ingestion, and accompanied by a similar response in the tuberal portion of SON (SOt). Rehydration for ten days after three days of 2% NaCl intake brought the percentage of cells with multiple nucleoli down to control levels. Cell area in SON cells paralleled nucleolar responses during dehydration and rehydration. The results demonstrate the sensitivity of nucleolar proliferation in SON to environmental changes ranging from osmotic to neurogenic stress.
皮下注射等渗盐水可使在注射后约5分钟处死的动物视上核神经元出现核仁增生。这种增生的程度在注射后4小时和8小时持续存在。注射聚乙二醇（PG）在注射后4小时和8小时使血容量减少，但这些动物中具有多个核仁的视上核细胞百分比与注射盐水的对照组并无差异。给大鼠饮用2%氯化钠而非水三天，视上核的前部（SOa）部分比对照组含有更多具有多个核仁的细胞。五天摄入后这种效应增强，并伴有视上核结节部（SOt）的类似反应。在摄入2%氯化钠三天后再补水十天，具有多个核仁的细胞百分比降至对照水平。视上核细胞的细胞面积在脱水和再水化过程中与核仁反应平行。结果表明视上核中核仁增生对从渗透应激到神经源性应激等环境变化敏感。
