Sugimoto T, Sawada T, Kusunoki T
Pediatr Res. 1979 Feb;13(2):91-5. doi: 10.1203/00006450-197902000-00001.
Several authors have observed that the plasma levels of carcinoembryonic antigen (CEA) in patients with neuroblastoma were significantly elevated. The present study was undertaken to investigate the nature of CEA activity in neuroblastoma tissue. This tumor tissue contains a small amount of CEA-like substance reacting with anti-CEA serum which is characterized by gamma-globulin electrophoretic mobility, a molecular weight that is approximately equal to that of albumin (4.6S) by gel filtration, and a glycoprotein staining with periodic acid-Schiff (PAS). According to the double immunodiffusion method, this antigen is partially identical to purified CEA of colon carcinoma, and is completely identical to nonspecific crossreacting antigen (NCA). This antigen is, therefore, referred to not as the CEA as described by Gold, but as NCA in neuroblastoma tissue. The elevation of plasma CEA activity in patients with neuroblastoma may be due to the release of NCA from tumor cells, or to the destruction tissues by metastasis, of normal which are rich in NCA, or to a combination of both.
几位作者观察到，神经母细胞瘤患者的血浆癌胚抗原（CEA）水平显著升高。本研究旨在探讨神经母细胞瘤组织中CEA活性的本质。这种肿瘤组织含有少量与抗CEA血清反应的CEA样物质，其特征为γ球蛋白电泳迁移率、通过凝胶过滤测得的分子量约等于白蛋白（4.6S）以及经高碘酸-希夫（PAS）染色的糖蛋白。根据双向免疫扩散法，这种抗原与纯化的结肠癌CEA部分相同，与非特异性交叉反应抗原（NCA）完全相同。因此，这种抗原在神经母细胞瘤组织中并非如戈尔德所描述的CEA，而是NCA。神经母细胞瘤患者血浆CEA活性升高可能是由于肿瘤细胞释放NCA，或由于富含NCA的正常组织因转移而被破坏，或两者兼而有之。
