Cush J J, Kavanaugh A F
University of Texas Southwestern Medical Center, Rheumatic Diseases Division, Dallas 75235-8577, USA.
Rheum Dis Clin North Am. 1995 Aug;21(3):797-816.
An increasing understanding of the immunopathogenesis of rheumatoid arthritis and advances in biotechnology have lead to the therapeutic application of immune-specific interventions. The complexity of this disorder has generated numerous investigations using a wide range of biologic interventions. This article presents the current and potential targets for such biopharmaceutical agents and discusses their utility in rheumatoid arthritis.
对类风湿关节炎免疫发病机制的深入理解以及生物技术的进步，促使了免疫特异性干预措施在治疗中的应用。这种疾病的复杂性引发了众多使用各种生物干预措施的研究。本文介绍了此类生物制药制剂的当前及潜在靶点，并讨论了它们在类风湿关节炎中的效用。
