Péterfy M, Hozier J C, Hall B, Gyuris T, Péterfy K, Takécs L
Department of Biomedical Science, Amgen, Inc., Thousand Oaks, California 91320, USA.
Somat Cell Mol Genet. 1995 Sep;21(5):345-9. doi: 10.1007/BF02257469.
Lissencephaly is a human brain malformation manifested by a smooth cerebral surface and severe mental retardation. Some of the patients have been shown to have deletions in chromosome 17p13.3, and recently, LIS-1 has been proposed to be the disease-associated gene. We have now mapped the mouse homolog of LIS-1 to mouse chromosome 11B3 by using fluorescence in situ hybridization to metaphase chromosomes. The analysis of yeast artificial chromosome clones placed Lis-1 in close proximity to the microsatellite marker D11Mit65.
无脑回畸形是一种人类脑部畸形，表现为大脑表面平滑和严重智力迟钝。一些患者已被证明在染色体17p13.3上存在缺失，最近，LIS-1被认为是与该疾病相关的基因。我们现在通过对中期染色体进行荧光原位杂交，将LIS-1的小鼠同源基因定位到小鼠染色体11B3上。对酵母人工染色体克隆的分析表明，Lis-1与微卫星标记D11Mit65紧密相邻。
