皮质类固醇对腺病毒复制的影响。
The effects of corticosteroids of adenoviral replication.
作者信息
Romanowski E G, Roba L A, Wiley L, Araullo-Cruz T, Gordon Y J
机构信息
Campbell Laboratory for Infectious Eye Diseases, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pa, USA.
出版信息
Arch Ophthalmol. 1996 May;114(5):581-5. doi: 10.1001/archopht.1996.01100130573014.
OBJECTIVE
To evaluate the effects of Pred Forte (prednisolone acetate; Allergan Pharmaceutical, Irvine, Calif) on the replication of different adenoviral serotypes in vitro and in the adenovirus type 5/New Zealand rabbit ocular model.
METHODS
The 50% inhibitory doses of Pred Forte and its components were determined for common ocular serotypes. The effects of continuous topical treatment with Pred Forte for 18 days were evaluated (eg, conjunctivitis, subepithelial immune infiltrates, and serial ocular viral titers) in the adenovirus 5/New Zealand rabbit ocular model.
RESULTS
Pred Forte and prednisolone acetate inhibited adenoviruses 1, 5, 8, and 19 in vitro. In vivo, 1% Pred Forte significantly reduced conjunctivitis (P = .04) and subepithelial infiltrates (P = .02), but enhanced viral replication (P = .01) on days 9 to 21 and increased the duration of viral shedding (P < .001).
CONCLUSIONS
Despite demonstrated anti-inflammatory and anti-immune effects, prolonged treatment of acute adenoviral infections with topical Pred Forte is not recommended because of the enhanced risks of viral transmission and community epidemics.
目的
评估强的松龙滴眼液（醋酸泼尼松龙；眼力健制药公司，加利福尼亚州欧文市）对不同腺病毒血清型在体外以及在5型腺病毒/新西兰兔眼部模型中复制的影响。
方法
测定强的松龙滴眼液及其成分对常见眼部血清型的50%抑制剂量。在5型腺病毒/新西兰兔眼部模型中评估连续局部应用强的松龙滴眼液18天的效果（如结膜炎、上皮下免疫浸润和系列眼部病毒滴度）。
结果
强的松龙滴眼液和醋酸泼尼松龙在体外可抑制1型、5型、8型和19型腺病毒。在体内，1%强的松龙滴眼液可显著减轻结膜炎（P = 0.04）和上皮下浸润（P = 0.02），但在第9至21天会增强病毒复制（P = 0.01）并延长病毒排出持续时间（P < 0.001）。
结论
尽管已证实有抗炎和免疫抑制作用，但由于病毒传播和群体流行风险增加，不建议长期局部应用强的松龙滴眼液治疗急性腺病毒感染。
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