三种多巴胺受体激动剂对MPTP处理的猴子的不同作用。

Differential effects of three dopamine receptor agonists in MPTP-treated monkeys.

作者信息

Arai N, Isaji M, Miyata H, Fukuyama J, Mizuta E, Kuno S

机构信息

Pharmacological Laboratories, Kissei Pharmaceutical Co. LTD, Nagano, Japan.

出版信息

J Neural Transm Park Dis Dement Sect. 1995;10(1):55-62. doi: 10.1007/BF02256629.

DOI:10.1007/BF02256629

PMID:8619909

Abstract

The behavioral effects of cabergoline, pergolide and bromocriptine were investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys with attention to the induction of hyperactivity, as evidenced by irritability, excitability and aggressiveness. All three drugs improved the parkinsonism in a dose-dependent fashion following a single injection. Among the three dopamine (DA) receptor agonists used, the antiparkinsonian effect of pergolide was the strongest and had an immediate effect, while cabergoline showed the longest duration of the antiparkinsonian effect and was least potent in inducing hyperactivity.

摘要

研究了卡麦角林、培高利特和溴隐亭对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）损伤的帕金森病食蟹猴的行为影响，重点关注多动的诱导情况，表现为易怒、易激惹和攻击性。单次注射后，所有三种药物均以剂量依赖性方式改善帕金森病症状。在所使用的三种多巴胺（DA）受体激动剂中，培高利特的抗帕金森病作用最强且起效迅速，而卡麦角林的抗帕金森病作用持续时间最长，且诱导多动的作用最小。