Renard L, Gicquel M, Laurentie M, Sanders P
Unité de pharmacocinétique, laboratoire des médicaments vétérinaires, Centre national d'études vétérinaires et alimentaires, La-Haute-Marche-Javené, Fougères, France.
Vet Res. 1996;27(1):23-32.
Pharmacodynamics studies consider three main parameters: the size of the bacterial population, the concentration of the antibiotic and the duration of its action. The pharmacodynamic characteristics of colistin were studied in vitro with Escherichia coli. The bacterial kinetics were fitted using differential equations. The mathematical model gave qualitative and quantitative information about the characteristics of the antibiotic-bacteria association. Above all, when linked to a pharmacokinetic model, the model permitted the prediction of the drug's efficiency. Simulations of various dosage levels in which the administration route, dose size, or interval between doses varied, permitted a more rational optimization than a prediction of efficacy based on the time taken to achieve antibiotic plasmatic concentrations above the minimal inhibitory concentration. Pharmacokinetic/pharmacodynamic modeling seems to be an interesting possibility for determining antibiotic dosing levels during the preclinical phase.
细菌群体的大小、抗生素的浓度及其作用持续时间。用大肠杆菌在体外研究了黏菌素的药效学特性。使用微分方程拟合细菌动力学。该数学模型给出了有关抗生素 - 细菌关联特征的定性和定量信息。最重要的是，当与药代动力学模型相结合时，该模型能够预测药物的疗效。对给药途径、剂量大小或给药间隔不同的各种剂量水平进行模拟，比基于达到高于最低抑菌浓度的抗生素血浆浓度所需时间来预测疗效能实现更合理的优化。药代动力学/药效学建模似乎是在临床前阶段确定抗生素给药水平的一种有趣方法。
