Squella J A, Letelier M E, Lindermeyer L, Nuñez-Vergara L J
Bioelectrochemistry Laboratory, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile.
Chem Biol Interact. 1996 Jan 5;99(1-3):227-38. doi: 10.1016/0009-2797(95)03672-5.
The electrochemical properties of nifuroxazide have been investigated in aqueous and aqueous-DMF mixed solvents. In aqueous media, a single, irreversible four-electron reduction occurs to give the hydroxylamine derivative. In mixed media, a reversible one-electron reduction to form a nitro radical anion takes place. Cyclic voltammetric studies show that the anion radical product is stable, although the nitro radical anion intermediate shows a tendency to undergo further chemical reactions. A comparison with the voltammetric behaviour of other nitrofurans such as nifurtimox, nitrofurazone and furazolidone is made. The electrochemically-obtained parameters are correlated with the in vivo studies of oxygen consumption on Trypanosoma cruzi cell suspensions.
已在水性和水性 - DMF混合溶剂中研究了硝呋拉嗪的电化学性质。在水性介质中，发生单一的、不可逆的四电子还原反应生成羟胺衍生物。在混合介质中，发生可逆的单电子还原反应形成硝基自由基阴离子。循环伏安研究表明，阴离子自由基产物是稳定的，尽管硝基自由基阴离子中间体有进一步发生化学反应的趋势。还对硝呋替莫、呋喃西林和呋喃唑酮等其他硝基呋喃的伏安行为进行了比较。电化学获得的参数与克氏锥虫细胞悬液耗氧量的体内研究相关。
