Lo D
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.
Clin Immunol Immunopathol. 1996 May;79(2):96-104. doi: 10.1006/clin.1996.0056.
The development of transgenic and knockout technologies has driven an explosion in new animal models of disease. These engineered diseases are a departure from previous animal models in that pathological syndromes are created from a priori assumptions about how disease pathogenesis could develop. Such models have been useful in providing new information on the functions of effector molecules such as cytokines, and in following the behavior of lymphocytes in vivo. However, the contrived nature of the systems might generate false information, unless validated by careful reference to human disease and spontaneous disease in other animal models.
转基因技术和基因敲除技术的发展推动了新型疾病动物模型的大量涌现。这些人工构建的疾病模型与以往的动物模型有所不同，其病理综合征是基于对疾病发病机制可能如何发展的先验假设而创建的。此类模型在提供有关细胞因子等效应分子功能的新信息以及追踪体内淋巴细胞行为方面很有用处。然而，除非通过仔细参照人类疾病和其他动物模型中的自发性疾病进行验证，否则这些系统的人为构建性质可能会产生虚假信息。
