转化生物医学研究中的人源化小鼠。

Humanized mice in translational biomedical research.

作者信息

Shultz Leonard D, Ishikawa Fumihiko, Greiner Dale L

机构信息

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

出版信息

Nat Rev Immunol. 2007 Feb;7(2):118-30. doi: 10.1038/nri2017.

DOI:10.1038/nri2017

PMID:17259968

Abstract

The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

摘要

对人源化小鼠数十年研究的成果正在推动我们在人类造血、固有免疫和适应性免疫、自身免疫、传染病、癌症生物学及再生医学等方面的理解取得进展。在本综述中，我们讨论了这些新一代人源化小鼠的发展情况、它们将如何促进多个生物医学学科的转化研究，以及克服这些模型尚存局限性的方法。