Escamilla R, Hermant C, Berjaud J, Mazerolles C, Daussy X
Service de Pneumo-Allergologie, Toulouse, France.
Eur Respir J. 1995 Nov;8(11):1982-4. doi: 10.1183/09031936.95.08111982.
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. Its origin remains unknown but in some cases a viral aetiology has been suggested. Recently primary pulmonary hypertension has been increasingly observed in patients with human immunodeficiency virus (HIV) infection, but only one case of pulmonary veno-occlusive disease has so far been described. We report the case of a 27 year old male intravenous drug abuser with HIV infection and pulmonary hypertension. Open lung biopsy led to the diagnosis of pulmonary veno-occlusive disease. This second case of pulmonary veno-occlusive disease raises the question of a relationship between HIV infection and lesions involving the pulmonary veins. However, the pathogenesis of vascular changes remains to be elucidated.
肺静脉闭塞性疾病（PVOD）是肺动脉高压的一种罕见病因。其起源尚不清楚，但在某些病例中提示有病毒病因。最近，人类免疫缺陷病毒（HIV）感染患者中越来越多地观察到原发性肺动脉高压，但迄今为止仅描述了1例肺静脉闭塞性疾病。我们报告1例27岁男性静脉吸毒者，患有HIV感染和肺动脉高压。开胸肺活检确诊为肺静脉闭塞性疾病。这例肺静脉闭塞性疾病的病例引发了HIV感染与累及肺静脉病变之间关系的问题。然而，血管变化的发病机制仍有待阐明。
