Pistorius L R, Funk M, Pattinson R C, Howarth G R
Department of Obstetrics and Gynecoogy, Kalafong Hospital, Pretoria, South Africa.
Int J Gynaecol Obstet. 1996 Jan;52(1):33-6. doi: 10.1016/0020-7292(95)02559-6.
The copper sulfate method of screening for anemia was evaluated to determine its accuracy in antenatal patients.
In an antenatal clinic in a tertiary referral center, which also serves a local urban black community, 100 antenatal patients were prospectively tested for anemia by Coulter hemoglobin analysis in comparison with the copper sulfate test. The respective accuracy and costs of the tests were evaluated.
Once initial technical difficulties had been overcome, the copper sulfate test proved accurate in detecting a hemoglobin level < 10 g% in pregnancy (sensitivity 94%, specificity 95%, positive predictive value 80%, negative predictive value 99%). The cost of the copper sulfate test is estimated to be less than 0.3% that of the Coulter test.
The copper sulfate test is accurate and inexpensive, and can be recommended for screening for anemia in pregnancy.
评估硫酸铜法筛查贫血的效果，以确定其在产前患者中的准确性。
在一家三级转诊中心的产前诊所（该诊所也服务于当地城市黑人社区），对100名产前患者进行前瞻性检测，采用库尔特血红蛋白分析法与硫酸铜试验对比检测贫血情况。对两种检测方法各自的准确性和成本进行评估。
一旦克服了最初的技术难题，硫酸铜试验在检测孕期血红蛋白水平<10 g%时被证明是准确的（灵敏度94%，特异度95%，阳性预测值80%，阴性预测值99%）。硫酸铜试验的成本估计不到库尔特试验成本的0.3%。
硫酸铜试验准确且成本低廉，可推荐用于孕期贫血筛查。
