Patel T, Gores G J, Kaufmann S H
Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
FASEB J. 1996 Apr;10(5):587-97. doi: 10.1096/fasebj.10.5.8621058.
The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.
蛋白酶在细胞凋亡过程中的重要性正日益显现。由于细胞凋亡与多种疾病进程相关，了解蛋白酶及其抑制剂所起的作用可能有助于深入了解这些病症的发病机制，并提出新的治疗策略。在这篇综述中，我们讨论了似乎参与凋亡过程的特定蛋白酶、底物和蛋白酶抑制剂的参与情况及作用。
