Mattern J, Volm M
German Cancer Research Center, Heidelberg, Germany.
Invasion Metastasis. 1995;15(3-4):81-94.
Drug resistance is an important problem in the treatment of lung cancer. Patients become resistant not only to the drugs used initially, but also to those to which they have not yet been exposed. Multiple mechanisms contribute to drug resistance in this disease, all or any combination of which may occur simultaneously within each cell, producing an overall drug-resistant phenotype. The limited success of hitherto applied strategies in their ability to circumvent drug resistance in lung cancer suggests that new approaches are required.
耐药性是肺癌治疗中的一个重要问题。患者不仅会对最初使用的药物产生耐药性，还会对他们尚未接触过的药物产生耐药性。多种机制导致了这种疾病的耐药性，在每个细胞内，所有这些机制或其中任何组合都可能同时发生，从而产生整体的耐药表型。迄今为止，应用策略在规避肺癌耐药性方面取得的成功有限，这表明需要新的方法。
