Koh Y Y, Lim H S, Min K U, Kim Y Y
Department of Pediatrics, Seoul National University College of Medicine, Korea.
J Asthma. 1996;33(1):55-65. doi: 10.3109/02770909609077763.
The changes in airway responsiveness between before and after exercise in asthma are not well defined. We investigated the effect of exercise on PC20 (bronchial sensitivity) and maximal airway narrowing (MAN) on the dose-response curve to methacholine in 56 mildly asthmatic children. High-dose methacholine inhalation tests were performed before and 7 hr after exercise challenge. Methacholine PC20 was not changed by exercise, irrespective of exercise-induced bronchoconstriction (EIB). However, the subjects with (+)EIB displayed increased MAN after exercise, whereas those with (+/-)EIB or (-)EIB did not. The results showed that EIB may be followed by increased MAN but not by the change of bronchial sensitivity.
哮喘患者运动前后气道反应性的变化尚不明确。我们研究了运动对56名轻度哮喘儿童在乙酰甲胆碱剂量反应曲线上的PC20（支气管敏感性）和最大气道狭窄（MAN）的影响。在运动激发前和激发后7小时进行高剂量乙酰甲胆碱吸入试验。无论运动诱发的支气管收缩（EIB）如何，运动均未改变乙酰甲胆碱PC20。然而，EIB（+）的受试者运动后MAN增加，而EIB（+/-）或（-）的受试者则没有。结果表明，EIB后可能会出现MAN增加，但支气管敏感性不会改变。
