T1/ST2受体假定配体的克隆
Cloning of a putative ligand for the T1/ST2 receptor.
作者信息
Gayle M A, Slack J L, Bonnert T P, Renshaw B R, Sonoda G, Taguchi T, Testa J R, Dower S K, Sims J E
机构信息
Immunex Corporation, Seattle, Washington 98101, USA.
出版信息
J Biol Chem. 1996 Mar 8;271(10):5784-9. doi: 10.1074/jbc.271.10.5784.
T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.
T1/ST2是一种与I型白细胞介素-1受体同源的受体样分子。尽管存在这种序列相似性，但我们仍无法证明T1/ST2与三种白细胞介素-1中的任何一种结合。在寻找T1/ST2的配体时，我们克隆了一种与之结合的细胞表面蛋白。在几种体外试验中，这种蛋白无法通过T1/ST2受体启动信号转导。
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