[肺气肿患者痰液中的白细胞介素-8]
[Interleukin-8 in sputum from patients with pulmonary emphysema].
作者信息
Yamamoto C, Yoneda T, Yoshikawa M, Fu A, Tokuyama T, Okamoto Y, Nakaya M, Tsukaguchi K, Kunimatsu M, Narita N
机构信息
Second Department of Internal Medicine, Nara Medical University, Japan.
出版信息
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Feb;34(2):174-9.
We measured concentrations of interleukin-8 (IL-8) in sputum from 38 patients with pulmonary emphysema, from 30 patients with bronchial asthma, and in induced sputum from 10 healthy subjects. Concentrations of IL-8 were significantly higher in sputum from patients with emphysema than in sputum from patients with asthma (mean +/- SE: 22,961 +/- 1,412 pg/ml and 9,135 +/- 1,590 pg/ml, respectively, p<0.0001) and were also higher than in sputum from healthy subjects (3,253+/-687 pg/ml, p<0.0001). Concentrations of IL-8 in sputum from patients with emphysema were unrelated to whether the patient was a current smoker or an ex-smoker, and did not correlate with concentrations of IL-8 in serum. Concentrations of IL-8 in sputum from patients with emphysema correlated significantly with FEV1% (r=-0.78, p<0.0001) and with %RV/TLC (r=0.63, p<0.01). These data suggest that IL-8 is mainly involved in chronic airway inflammation and that concentrations of IL-8 in sputum are closely related to airflow obstruction in patients with pulmonary emphysema.
我们检测了38例肺气肿患者、30例支气管哮喘患者痰液中白细胞介素-8（IL-8）的浓度，以及10名健康受试者诱导痰中IL-8的浓度。肺气肿患者痰液中IL-8的浓度显著高于哮喘患者痰液中的浓度（平均值±标准误：分别为22,961±1,412 pg/ml和9,135±1,590 pg/ml，p<0.0001），也高于健康受试者痰液中的浓度（3,253±687 pg/ml，p<0.0001）。肺气肿患者痰液中IL-8的浓度与患者是当前吸烟者还是既往吸烟者无关，且与血清中IL-8的浓度无相关性。肺气肿患者痰液中IL-8的浓度与第一秒用力呼气容积百分比（FEV1%）显著相关（r = -0.78，p<0.0001），与残气量/肺总量百分比（%RV/TLC）也显著相关（r = 0.63，p<0.01）。这些数据表明，IL-8主要参与慢性气道炎症，且肺气肿患者痰液中IL-8的浓度与气流阻塞密切相关。
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