Hendrich C, Hüttmann G, Diddens H, Seara J, Siebert W E
Orthopädische Universitätsklinik, König-Ludwig-Haus, Würzburg.
Orthopade. 1996 Feb;25(1):30-6.
The principle of photodynamic laser therapy (PDT) for chronic polyarthritis consists in specifically concentrating a drug (photosensitizer) in the synovium. Subsequent activation of the photosensitizer by means of laser leads to a cytotoxic effect. The practicability of PDT was first shown in cell cultures of human synovial fibroblasts. For further tests an animal model consisting of IgG-induced arthritis in rabbits was used. In this model, concentration of the photosensitizer in the synovial lining cells, in the media of arteries and in the lymphoid infiltrate was seen. After laser irradiation there was total selective demarcation of the synovium. In contrast, bradytrophic tissues such as cartilage, meniscus and ligament structures were changed neither macroscopically nor microscopically. In the animal model PDT combines high selectivity with minimal invasiveness and can be used in small joints. PDT thus offers ideal preconditions for future minimal invasive treatment of chronic inflammatory joint diseases.
用于慢性多关节炎的光动力激光疗法（PDT）的原理在于将一种药物（光敏剂）特异性地聚集在滑膜中。随后通过激光激活光敏剂会产生细胞毒性作用。PDT的实用性最初在人滑膜成纤维细胞的细胞培养中得到证实。为了进一步测试，使用了由兔IgG诱导性关节炎构成的动物模型。在这个模型中，观察到光敏剂在滑膜衬里细胞、动脉介质和淋巴浸润中聚集。激光照射后，滑膜出现完全选择性分界。相比之下，诸如软骨、半月板和韧带结构等营养障碍性组织在宏观和微观上均未发生改变。在动物模型中，PDT兼具高选择性和微创性，可用于小关节。因此，PDT为未来慢性炎症性关节疾病的微创治疗提供了理想的前提条件。
