Roullet P, Lassalle J M
Laboratoire d'Ethologie et de Psychophysiologie, E-A-MESR 1367, UFR Sciences et Techniques, Tours, France.
Physiol Behav. 1995 Dec;58(6):1189-95. doi: 10.1016/0031-9384(95)02066-7.
Spatial working memory on the radial maze was studied in 8 groups of isogenic mice. The device and procedure were specially designed to prevent the mice from using a response strategy or taking advantage of olfactory trails or other proximal cues. The results showed that the strains of mice were clearly split between those which succeeded (C57BL/6, DBA/2, CB6F1, B6D2F1) and those which failed (NZB, CBA, C3H/HE, BALB/c) to learn the task. A second experiment established that when more extended training was given, the four strains which had performed poorly in experiment 1 still did not improve their performance. In the conclusion, we discuss the possible reasons for the deficits of nonlearners and emphasize the importance of using proper tools to ensure the unambiguous assessment of the cognitive processes underlying behavioral adaptation.
在8组同基因小鼠中研究了其在放射状迷宫上的空间工作记忆。该装置和程序经过特殊设计，以防止小鼠使用反应策略或利用嗅觉痕迹或其他近端线索。结果显示，在学习该任务方面，小鼠品系明显分为成功的（C57BL/6、DBA/2、CB6F1、B6D2F1）和失败的（NZB、CBA、C3H/HE、BALB/c）两类。第二个实验表明，当给予更长时间的训练时，在实验1中表现不佳的四个品系仍然没有提高其表现。在结论中，我们讨论了非学习者表现缺陷的可能原因，并强调了使用适当工具以确保对行为适应背后的认知过程进行明确评估的重要性。
