Kalaria R N, Cohen D L, Premkumar D R
Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Ann N Y Acad Sci. 1996 Jan 17;777:266-70. doi: 10.1111/j.1749-6632.1996.tb34430.x.
The presence of apolipoprotein E (ApoE)-E4 allele has been implicated as a risk factor for Alzheimer's disease (AD). We examined the occurrence of ApoE 4 alleles in AD associated with cerebral amyloid angiopathy and other vascular lesions. We found significantly high frequency of the ApoE 4 allele in AD with moderate to severe CAA. The frequency of the allele was also high in AD cases with other vascular lesions such as multiple infarcts and lacunes. As previously reported, we confirm a greater frequency of the ApoE 4 allele in the diffuse Lewy body variant of AD. Our results suggest ApoE 4 allele to be a significant factor in the development of CAA in AD. While this may be related to increased brain amyloid load as a consequence of ApoE genotype, the possibility exists that ApoE may be a specific factor in vascular abnormalities associated with AD.
载脂蛋白E（ApoE）-E4等位基因的存在已被认为是阿尔茨海默病（AD）的一个风险因素。我们研究了与脑淀粉样血管病及其他血管病变相关的AD中ApoE 4等位基因的出现情况。我们发现，在伴有中度至重度CAA的AD中，ApoE 4等位基因的频率显著升高。在伴有其他血管病变（如多发性梗死和腔隙）的AD病例中，该等位基因的频率也很高。正如之前所报道的，我们证实AD的弥漫性路易体变异型中ApoE 4等位基因的频率更高。我们的结果表明，ApoE 4等位基因是AD中CAA发生发展的一个重要因素。虽然这可能与ApoE基因型导致的脑淀粉样蛋白负荷增加有关，但ApoE可能是与AD相关的血管异常中的一个特定因素，这种可能性是存在的。
