Gebicka L, Gebicki J L
Institute of Applied Radiation Chemistry, Technical University of Lódź, Poland.
Biochem Mol Biol Int. 1995 Nov;37(5):1021-6.
It has been shown that dimethyl sulfoxide competes with the enzyme substrate towards horseradish peroxidase compound I, but probably not towards horseradish peroxidase compound II. Dimethyl sulfoxide may hinder the reaction of superoxide with horseradish peroxidase compound II by modifying heme center. In this connection dimethyl sulfoxide is not recommended as a solvent in catalytic studies of horseradish peroxidase.
已经表明，二甲基亚砜与酶底物竞争辣根过氧化物酶化合物I，但可能不与辣根过氧化物酶化合物II竞争。二甲基亚砜可能通过修饰血红素中心来阻碍超氧化物与辣根过氧化物酶化合物II的反应。就此而言，不建议在辣根过氧化物酶的催化研究中使用二甲基亚砜作为溶剂。
