Kang S B, Kim B G, Song Y S, Lee H P
Department of Obstetrics and Gynecology, Seoul National University Hospital, College of Medicine, Seoul National University, Korea.
J Obstet Gynaecol Res. 1996 Feb;22(1):67-71. doi: 10.1111/j.1447-0756.1996.tb00939.x.
To examine the relationship between calculated and measured creatinine clearance, and also to evaluate the clinical utility of calculated creatinine clearance before administration of chemotherapy in patients with gynecologic malignancies.
In 38 patients with gynecologic malignancies, a total-69 paired creatinine clearance measured by 24-hour urinary creatinine clearance and calculated were compared.
The significant correlation (r = 0.597, p < 0.0001) was observed between creatinine clearances determined by both methods. There were 26 (37.7%) 24-hour urine collections. The correlation between two methods improved when these inaccurate samples were excluded (r = 0.876, p < 0.0001). In addition, if a creatinine clearance of 50 ml/min is set as a threshold for dose modification, only 2.9% of the patients would have received reduced doses inappropriately, by using the calculated creatinine clearance alone.
These results suggest that in patients with gynecologic malignancies, a calculated creatinine clearance prior to chemotherapy is sufficient for evaluation of renal function and measured creatinine clearance would be determined only when calculated creatinine clearance is below the threshold for dose modification.
研究计算得出的肌酐清除率与测量得到的肌酐清除率之间的关系，并评估妇科恶性肿瘤患者化疗前计算肌酐清除率的临床应用价值。
对38例妇科恶性肿瘤患者进行研究，比较通过24小时尿肌酐清除率测量得到的和计算得出的总共69对肌酐清除率。
两种方法测定的肌酐清除率之间存在显著相关性（r = 0.597，p < 0.0001）。有26例（37.7%）进行了24小时尿液收集。排除这些不准确的样本后，两种方法之间的相关性有所提高（r = 0.876，p < 0.0001）。此外，如果将肌酐清除率50 ml/min设定为剂量调整阈值，仅使用计算得出的肌酐清除率时，只有2.9%的患者会不恰当地接受降低剂量。
这些结果表明，对于妇科恶性肿瘤患者，化疗前计算得出的肌酐清除率足以评估肾功能，只有当计算得出的肌酐清除率低于剂量调整阈值时才需要测定测量得到的肌酐清除率。
