肝脏胆汁酸摄取的种属差异：大鼠和兔中牛磺胆酸盐和牛磺熊去氧胆酸盐摄取的比较评估
Species differences in hepatic bile acid uptake: comparative evaluation of taurocholate and tauroursodeoxycholate extraction in rat and rabbit.
作者信息
Montagnani M, Aldini R, Roda A, Caruso M L, Gioacchini A M, Lenzi P L, Roda E
机构信息
Cattedra di Gastroenterologia, Università di Bologna, Italy.
出版信息
Comp Biochem Physiol A Physiol. 1996 Feb;113(2):157-64. doi: 10.1016/0300-9629(95)02047-0.
Dose-response curves for taurocholate and tauroursodeoxycholate were performed in rat and rabbit livers to get more insight into species differences in the hepatic bile acid uptake. The bile acids showed saturation kinetics in both animals, the Vmax in rat being higher than in rabbit and the Km being lower in the rat than in the rabbit for both the bile acids, with no significant difference in the hepatic cells morphometric parameters. Therefore, it is possible that differences in the kinetic parameters are related to the number and, to a lesser extent, to the affinity of the transporters on the sinusoidal plasma membranes.
为了更深入了解肝胆汁酸摄取的种属差异，在大鼠和兔肝脏中进行了牛磺胆酸盐和牛磺熊去氧胆酸盐的剂量反应曲线实验。两种胆汁酸在两种动物中均呈现饱和动力学，两种胆汁酸的大鼠Vmax均高于兔，大鼠的Km低于兔，肝细胞形态计量学参数无显著差异。因此，动力学参数的差异可能与窦状质膜上转运体的数量有关，在较小程度上也与转运体的亲和力有关。
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