Nakaizumi A, Tatsuta M, Uehara H, Takenaka A, Iishi H, Kitamra T, Ohigashi H, Ishikawa O, Okuda S, Wada A
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Cancer. 1995 Sep 1;76(5):750-7. doi: 10.1002/1097-0142(19950901)76:5<750::aid-cncr2820760507>3.0.co;2-#.
The early diagnosis of pancreatic carcinoma through the use of traditional radiographic or ultrasonographic methods is extremely difficult.
To detect an early and potentially curable cancer of the pancreas, endoscopic retrograde pancreatography (ERP) and aspiration cytology of pure pancreatic juice were performed in 295 consecutive patients who had symptoms or findings that suggested pancreatic disease but in whom there was neither a pancreatic mass nor ductal stenosis.
Positive cytologic results were obtained in 12 patients (4%). With the aid of intraoperative cytodiagnosis, all 12 early neoplasms of the pancreas were successfully resected. Of these 12 resected specimens, 4 were adenocarcinoma with minimal invasion, 3 were in situ adenocarcinoma and 5 were marked atypia. All 12 patients were alive with no evidence of recurrence for an average of 32 months after surgery. The 283 patients who had negative ERP-cytology results were observed, but no further cases of pancreatic cancer were found.
Because ERP-cytology is simple to perform, safe, and reliable, it is useful in the diagnosis of patients who have early neoplasm of the pancreas.
通过传统的放射学或超声检查方法早期诊断胰腺癌极其困难。
为了检测早期且可能治愈的胰腺癌，对295例有提示胰腺疾病的症状或体征但既无胰腺肿块也无导管狭窄的连续患者进行了内镜逆行胰胆管造影（ERP）及纯胰液抽吸细胞学检查。
12例患者（4%）获得了阳性细胞学结果。借助术中细胞诊断，所有12例胰腺早期肿瘤均成功切除。在这12例切除标本中，4例为微浸润腺癌，3例为原位腺癌，5例为显著异型增生。所有12例患者术后平均存活32个月，无复发迹象。对ERP细胞学检查结果为阴性的283例患者进行了观察，但未发现更多胰腺癌病例。
由于ERP细胞学检查操作简单、安全且可靠，它对胰腺早期肿瘤患者的诊断很有用。
