细胞凋亡与转移：转移性癌细胞对程序性细胞死亡具有更强的抗性。
Apoptosis amd metastasis: a superior resistance of metastatic cancer cells to programmed cell death.
作者信息
Glinsky G V, Glinsky V V
机构信息
Cancer Research Center and Department of Biochemistry, University of Missouri-Columbia, 65201, USA.
出版信息
Cancer Lett. 1996 Mar 19;101(1):43-51. doi: 10.1016/0304-3835(96)04112-2.
PMID:8625281
Abstract
We studied the response to different external signals leading to apoptosis of several poorly and highly metastatic cell lines employing a murine B16 melanoma experimental metastasis model. We found that highly metastatic cells exhibit a superior survival ability and resistance to apoptosis compared to poorly metastatic cells which would give the former an obvious selective growth advantage during tumor progression. Our results indicate that there is a genetic link between aggressive metastatic phenotype and resistance to apoptosis.
摘要
我们利用小鼠B16黑色素瘤实验性转移模型，研究了几种低转移性和高转移性细胞系对导致细胞凋亡的不同外部信号的反应。我们发现，与低转移性细胞相比，高转移性细胞具有更强的生存能力和抗凋亡能力，这将使前者在肿瘤进展过程中具有明显的选择性生长优势。我们的结果表明，侵袭性转移表型与抗凋亡之间存在遗传联系。
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