Kaden J, Groth J, Eckert H
Acta Biol Med Ger. 1978;37(8):1247-53.
Inbred mice of the B10LP strain were injected subcutaneously over a period of 28 days with chloromadinone acetate, mestranol, both hormones together, and the carrier alone. Treatment with the gestagen chloromadinone acetate alone or in combination with mestranol caused a significant prolongation of the H-2 different skin graft survival. This was not seen after mestranol treatment alone. All the hormone-treated mice developed characteristic cysts in the thymic medulla and changes in the concentration of some plasma proteins, e.g. a fall of albumin level and a simultaneous increase of glycoprotein level. Therefore, it is necessary to look for such side-effects in humans also to prevent or to notice early alterations of immunological surveillance.
在28天的时间里，给近交系B10LP小鼠皮下注射醋酸氯地孕酮、炔雌醇甲醚、两种激素的组合以及单独的载体。单独使用孕激素醋酸氯地孕酮或与炔雌醇甲醚联合使用，可显著延长H-2不同皮肤移植物的存活时间。单独使用炔雌醇甲醚治疗后未出现这种情况。所有接受激素治疗的小鼠在胸腺髓质中都出现了特征性囊肿，并且一些血浆蛋白的浓度发生了变化，例如白蛋白水平下降，糖蛋白水平同时升高。因此，有必要在人类中也寻找此类副作用，以预防或尽早发现免疫监测的改变。
