Mattheij J A
Endocr Res Commun. 1977;4(1):1-9. doi: 10.1080/07435807709045729.
Adult rats were subjected to hydration and dehydration experiments. Blood samples were obtained via indwelling jugular cannulae or after rapid decapitation. In the experiments attention was given to the avoidance of stress. Intravenous infusion with 5 ml distilled water in 50 minutes in males and lactating females did not affect the plasma prolactin (PRL) concentration, although it caused a significant drop in plasma osmolarity. Dehydration obtained by injecting furosemide, while resulting in a marked increase in plasma osmolarity, had no effect on the plasma PRL level in male rats. Thirst experiments for 2, 3 and 4 days, which likewise caused a rise in plasma osmotic value, had no significant influence on plasma PRL. It is concluded that PRL in the adult rat is not important in water retention or for the regulation of plasma osmolarity.
成年大鼠接受了水合和脱水实验。通过颈静脉插管或快速断头后采集血样。实验过程中注意避免应激。雄性和哺乳期雌性大鼠在50分钟内静脉输注5毫升蒸馏水，虽然导致血浆渗透压显著下降，但对血浆催乳素（PRL）浓度没有影响。注射速尿导致脱水，虽然使血浆渗透压显著升高，但对雄性大鼠的血浆PRL水平没有影响。进行2、3和4天的口渴实验同样导致血浆渗透压升高，但对血浆PRL没有显著影响。得出的结论是，成年大鼠体内的PRL在保水或调节血浆渗透压方面并不重要。
