Kay R M, Eckardt J J, Mirra J M
Department of Orthopaedic Surgery, University of California, Los Angeles School of Medicine, 90095-6902, USA.
Clin Orthop Relat Res. 1996 Feb(323):284-7. doi: 10.1097/00003086-199602000-00039.
Retinoblastoma, though uncommon, frequently is associated with other second malignant neoplasms, especially bone sarcomas. These second neoplasms can occur in sporadic cases of retinoblastoma, though they more commonly are associated with genetic forms of the disease. This is the first known report of 2 histologically distinct bone sarcomas in a patient with retinoblastoma.
视网膜母细胞瘤虽不常见,但常与其他继发性恶性肿瘤相关,尤其是骨肉瘤。这些继发性肿瘤可发生于视网膜母细胞瘤的散发病例中,不过它们更常与该疾病的遗传形式相关。这是关于一名视网膜母细胞瘤患者出现两种组织学上不同的骨肉瘤的首次已知报告。