O'Connor M D, Landahl H D, Grodsky G M
Endocrinology. 1977 Jul;101(1):85-8. doi: 10.1210/endo-101-1-85.
In the isolated perfused pancreas, the amount of insulin secreted in response to a glucose stimulus was evaluated as a function of the maximum rate of change of the stimulus. Range of glucose concentration, total amount of glucose, total duration of the changing stimulus, the average concentration, and the average rate of change of concentration were the same. Fast changes stimulated more insulin secretion than slow changes, indicating that the rate-sensor property was inherent in the control of insulin release.
在离体灌注胰腺中，将响应葡萄糖刺激分泌的胰岛素量评估为刺激最大变化率的函数。葡萄糖浓度范围、葡萄糖总量、变化刺激的总持续时间、平均浓度以及浓度的平均变化率均相同。快速变化比缓慢变化刺激更多的胰岛素分泌，这表明速率传感器特性是胰岛素释放控制所固有的。
