Ohtsuka K, Hasegawa K, Yamagiwa S, Sato K, Nakayama M, Watanabe H, Asakura H, Abo T
Department of Immunology, Niigata University School of Medicine, Japan.
Dig Dis Sci. 1996 May;41(5):902-11. doi: 10.1007/BF02091529.
Recently, properties of intraepithelial lymphocytes (IEL) in the colon (C-IEL) have been analyzed in comparison with those of IEL in the small intestine (SI-IEL). We compared the properties of C-IEL with those of SI-IEL and hepatic intermediate TCR cells, two other types of extrathymic T cells. C-IEL and intermediate TCR cells contain many NK1+T cells, although SI-IEL contain few. V gamma and V delta usage of C-IEL was the same as that SI-IEL, and that of intermediate TCR cells was different. C-IEL responded to Con A while SI-IEL did not. As to adhesion molecules, C-IEL include both extrathymic and thymus-originated type T cells. With age, TCR- alpha beta(+) CD4+ CD8+ cells do not increase among C-IEL but do increase among SI-IEL. IL-2R beta(+) or CD4- CD8- C-IEL increase as observed in the liver. These results indicate that these organ-specific T cells have different roles at their respective sites and that they may be of different lineages.
最近，已对结肠上皮内淋巴细胞（C-IEL）的特性与小肠上皮内淋巴细胞（SI-IEL）的特性进行了比较分析。我们将C-IEL的特性与SI-IEL以及另外两种胸腺外T细胞类型——肝中间型TCR细胞的特性进行了比较。C-IEL和中间型TCR细胞含有许多NK1 + T细胞，而SI-IEL含有的此类细胞很少。C-IEL的Vγ和Vδ使用情况与SI-IEL相同，而与中间型TCR细胞不同。C-IEL对刀豆蛋白A有反应，而SI-IEL则无反应。至于黏附分子，C-IEL包括胸腺外起源型和胸腺起源型T细胞。随着年龄增长，TCR-αβ(+) CD4 + CD8 +细胞在C-IEL中不增加，但在SI-IEL中增加。如在肝脏中观察到的那样，IL-2Rβ(+)或CD4 - CD8 - C-IEL增加。这些结果表明，这些器官特异性T细胞在各自的部位发挥不同的作用，并且它们可能来自不同的谱系。
