新型抗肿瘤抗生素——耳蜗霉素的研究。III. 耳蜗霉素的生物合成：13C和2H标记化合物掺入耳蜗霉素的情况。
Studies on cochleamycins, novel antitumor antibiotics. III. Biosyntheses of cochleamycins: incorporation of 13C- and 2H-labeled compounds into cochleamycins.
作者信息
Shindo K, Sakakibara M, Kawai H, Seto H
机构信息
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
出版信息
J Antibiot (Tokyo). 1996 Mar;49(3):249-52. doi: 10.7164/antibiotics.49.249.
PMID:8626239
Abstract
Biosynthetic studies using 13C- and 2H-labeled compounds revealed that the carbon skeletons of cochleamycins A and B were derived from eight acetic acid units and one propionic acid unit with the introduction of an acetoxy group at C-10, which was replaced by an isobutyryl residue derived from valine in cochleamycins A2 and B2.
摘要
使用13C和2H标记化合物的生物合成研究表明，耳蜗霉素A和B的碳骨架源自八个乙酸单元和一个丙酸单元，并在C-10处引入了一个乙酰氧基，在耳蜗霉素A2和B2中该乙酰氧基被缬氨酸衍生的异丁酰基残基取代。
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