Piddock L J, Jin Y F
Department of Infection, Medical School, University of Birmingham, UK.
J Antimicrob Chemother. 1995 Nov;36(5):845-50. doi: 10.1093/jac/36.5.845.
For wild-type bacteria the activity of biapenem was similar to that of imipenem, but for 51 imipenem-resistant strains meropenem was more active than either. When penicillin-binding protein 2a (PBP 2a) was expressed in Staphylococcus aureus biapenem had reduced activity. Mutant bacteria with decreased susceptibility to biapenem were selected in agar. Most of the mutant Gram negative bacteria were unstable and readily reverted to susceptible. The mutant Proteus vulgaris and Pseudomonas aeruginosa lacked an outer membrane protein. Biapenem-resistant S. aureus could be selected only from MRSA.
对于野生型细菌，比阿培南的活性与亚胺培南相似，但对于51株耐亚胺培南菌株，美罗培南的活性比两者都更强。当青霉素结合蛋白2a（PBP 2a）在金黄色葡萄球菌中表达时，比阿培南的活性降低。在琼脂中筛选出对比阿培南敏感性降低的突变细菌。大多数突变革兰氏阴性菌不稳定，容易回复为敏感型。突变的普通变形杆菌和铜绿假单胞菌缺乏一种外膜蛋白。耐比阿培南的金黄色葡萄球菌只能从耐甲氧西林金黄色葡萄球菌（MRSA）中筛选得到。
