Frenzel J, Bräunlich H, Schramm D, Kersten L, Zwacka G
Eur J Clin Pharmacol. 1977 Apr 20;11(4):317-20. doi: 10.1007/BF00607683.
In newborn infants of various ages, the influence of repeated administration of water and electrolytes on renal excretion of urine, sodium, potassium, free and bound hydrogen ions and on urine osmolarity was studied. In 14- and 21-day-old infants the repeated administration of water and electrolytes was followed by diminution of renal excretion of hydrogen ions and potassium, possibly caused by stimulation of hormonal regulation of ion exchange in the kidney. In animal studies performed with a larger water and electrolyte load, stimulation of renal excretion of sodium was caused by the pretreatment.
在不同年龄段的新生儿中，研究了反复给予水和电解质对尿液、钠、钾、游离和结合氢离子的肾排泄以及尿渗透压的影响。在14日龄和21日龄的婴儿中，反复给予水和电解质后，氢离子和钾的肾排泄减少，这可能是由于肾脏离子交换的激素调节受到刺激所致。在给予更大水和电解质负荷的动物研究中，预处理导致钠的肾排泄受到刺激。
