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Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.

作者信息

Harfenist M, Heuser D J, Joyner C T, Batchelor J F, White H L

机构信息

Division of Organic Chemistry, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709, USA.

出版信息

J Med Chem. 1996 Apr 26;39(9):1857-63. doi: 10.1021/jm950595m.

DOI:10.1021/jm950595m
PMID:8627609
Abstract

Inhibition of monoamine oxidase A (MAO A) is believed to cause antidepressant and possibly antianxiety effects. The previous paper had developed structure-activity relationships (SAR) for in vitro MAO A inhibition by tricyclic N-arylamides. It is shown in this paper that the same in vitro SAR can be carried over to tricyclics whose potentially toxic amide function is replaced by an appropriately substituted imidazoline, a 1,2,4- or 1,3,4-oxadiazole, or an alkylated tetrazole moiety. Dialysis of the inhibitor from the enzyme was used as a measure of reversibility which correlates with a low ability to cause a blood pressure rise with ingested tyramine ("cheese effect").

摘要

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