Schlegel P N, Shin D, Goldstein M
Center for Male Reproductive Medicine and Microsurgery, James Buchanan Brady Foundation, New York, USA.
J Urol. 1996 May;155(5):1644-8.
We evaluated urogenital anomalies in men with congenital absence of the vas deferens.
A retrospective review was done of 104 subfertile men with congenital absence of the vas deferens (84 bilaterally and 20 unilaterally).
Of men with unilateral or bilateral congenital absence of the vas deferens 26 and 11%, respectively, had renal agenesis. Of men with unilateral congenital absence of the vas deferens and infertility 80% had genitourinary anamalies affecting the contralateral testis. No man with congenital absence of the vas deferens and renal anomalies had cystic fibrosis transmembrane-conductance regulator (CFTR) gene mutations detected.
Other urogenital anomalies are common for men with congenital absence of the vas deferens. CFTR gene mutations frequently contribute to maldevelopment of the vas deferens but vasal agenesis can occur without any evidence of CFTR defects. CFTR abnormalities are rarely detected in men with congenital absence of the vas deferens and renal anomalies.
我们评估了先天性输精管缺如男性的泌尿生殖系统异常情况。
对104例先天性输精管缺如的不育男性进行了回顾性研究（双侧84例，单侧20例）。
单侧或双侧先天性输精管缺如的男性中，分别有26%和11%存在肾缺如。单侧先天性输精管缺如且不育的男性中，80%有影响对侧睾丸的泌尿生殖系统异常。先天性输精管缺如且有肾脏异常的男性未检测到囊性纤维化跨膜传导调节因子（CFTR）基因突变。
其他泌尿生殖系统异常在先天性输精管缺如的男性中很常见。CFTR基因突变常导致输精管发育不良，但输精管缺如可在无任何CFTR缺陷证据的情况下发生。先天性输精管缺如且有肾脏异常的男性很少检测到CFTR异常。
