大袋鼠疱疹病毒2对选定抗疱疹化合物的体外敏感性

In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds.

作者信息

Smith G

机构信息

Queensland Agricultural Biotechnology Centre, Queensland Department of Primary Industries, University of Queensland, St. Lucia, Australia.

出版信息

J Wildl Dis. 1996 Jan;32(1):117-20. doi: 10.7589/0090-3558-32.1.117.

DOI:10.7589/0090-3558-32.1.117

PMID:8627922

Abstract

We tested the in vitro sensitivity of Macropodid Herpesvirus 2 to eight commonly used anti-herpetic compounds using plaque reduction tests, March and April, 1995. The virus was most susceptible to inhibition by (E)-5-(2'-bromovinyl)-2'-deoxyuridine and adenine 9-beta-D-arabino-furanoside. Both compounds have been used for anti-herpetic therapy in humans and may prove useful in the treatment of macropodoids in captivity.

摘要

1995年3月和4月，我们使用蚀斑减少试验检测了巨足袋貂疱疹病毒2对八种常用抗疱疹化合物的体外敏感性。该病毒对（E）-5-（2'-溴乙烯基）-2'-脱氧尿苷和腺嘌呤9-β-D-阿拉伯呋喃糖苷的抑制最为敏感。这两种化合物都已用于人类抗疱疹治疗，可能对圈养巨足袋貂的治疗有用。