甘丙肽对培养的大鼠垂体生长激素分泌腺瘤细胞（GH1）生长激素（GH）对促甲状腺激素释放激素反应的影响。
Effect of galanin on growth hormone (GH) response to thyrotropin releasing hormone of rat pituitary GH-secreting adenomatous cells (GH1) in culture.
作者信息
Giustina A, Bonfanti C, Licini M, Stefana B, Ragni G, Turano A
机构信息
Sezione di Endocrinologia, Clinica Medica, School of Medicine, University of Brescia, Italy.
出版信息
Life Sci. 1996;58(1):83-90. doi: 10.1016/0024-3205(95)02258-9.
The growth hormone (GH) releasing effect of thyrotropin-releasing hormone (TRH) and galanin, a 29-amino acid peptide widely distributed in mammalian CNS, alone or in combination was investigated in cultured rat pituitary tumor cells (GH1). TRH stimulated GH secretion in GH1 cells (maximal stimulation at the dose of 0.1 microM). Galanin alone had a significant GH inhibitory effect in GH1 cells at all the doses used. When the two peptides were administered in combination, no significant changes as compared to baseline levels were observed. The results of this study indicate that galanin has potent direct inhibitory effects on baseline and TRH-stimulated GH release from rat tumor cells.
研究了促甲状腺激素释放激素（TRH）和甘丙肽（一种广泛分布于哺乳动物中枢神经系统的29个氨基酸的肽）单独或联合使用时对培养的大鼠垂体肿瘤细胞（GH1）的生长激素（GH）释放作用。TRH刺激GH1细胞分泌GH（在0.1微摩尔剂量时达到最大刺激）。单独使用甘丙肽在所有使用剂量下对GH1细胞都有显著的GH抑制作用。当两种肽联合使用时，与基线水平相比未观察到显著变化。本研究结果表明，甘丙肽对大鼠肿瘤细胞的基线和TRH刺激的GH释放具有强大的直接抑制作用。
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