Agar N S, Gruca M A, Hellquist L N, Harley J D, Roberts J
Experientia. 1977 May 15;33(5):670-1. doi: 10.1007/BF01946566.
Based on the observations made on human and dog red blood cells, it was recently proposed that the response of red cell glycolysis to variations in the levels of specific cations in an evolutionary adaptation in response to a specific cellular environment. We have now examined the effect of K+ and Na+ on the activity of pyruvate kinase (PK) in the red blood cells from 2 genetically different types of sheep high potassium (HK) and low potassium (LK). The results indicate that K+ stimulate glucose consumption and the activity of PK in both types of sheep. It thus appears that red cell PK from LK sheep does not fit into the concept of cellular environment and PK activity.
基于对人类和狗红细胞的观察，最近有人提出，红细胞糖酵解对特定阳离子水平变化的反应是一种针对特定细胞环境的进化适应。我们现在研究了钾离子（K+）和钠离子（Na+）对两种遗传类型不同的绵羊（高钾（HK）和低钾（LK））红细胞中丙酮酸激酶（PK）活性的影响。结果表明，K+可刺激两种类型绵羊的葡萄糖消耗和PK活性。因此，LK绵羊的红细胞PK似乎不符合细胞环境和PK活性的概念。
