阿尔茨海默病：通过使用三维立体定向表面投影改善PET图像的视觉解读

Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections.

作者信息

Burdette J H, Minoshima S, Vander Borght T, Tran D D, Kuhl D E

机构信息

Department of Radiology, University of Michigan Medical Center, University Hospital, Ann Arbor 48109-0028, USA.

出版信息

Radiology. 1996 Mar;198(3):837-43. doi: 10.1148/radiology.198.3.8628880.

DOI:10.1148/radiology.198.3.8628880

PMID:8628880

Abstract

PURPOSE

To compare the diagnostic usefulness of three-dimensional (3D) stereotaxic surface projection (SSP) with that of standard transaxial display in brain positron emission tomography (PET) in Alzheimer disease (AD).

MATERIALS AND METHODS

Standard transaxial section display and 3D-SSP PET image sets obtained after administration of 2-deoxy-2-[fluorine-18]fluoro-D-glucose in 39 patients with probable AD (aged 53-82 years; 15 men, 24 women) and 40 subjects without AD (aged 21-78 years; 14 men, 26 women) were randomly interpreted. Receiver operating characteristic (ROC) analysis was performed.

RESULTS

Diagnostic performance was superior with 3D SSP (Az[section]=0.94,Az[3D SSP]=0.99[Az=area under the ROC curve];P=.043). With 3D SSP, diagnosis of AD was equally good in beginners and experts. The sensitivity and specificity in questionable or mild dementia were 94% and 99% with 3D SSP and 79% and 88% with standard transaxial display.

CONCLUSION

Accuracy of detecting AD was improved in PET with 3D SSP.

摘要

目的

比较三维（3D）立体定向表面投影（SSP）与标准横轴位显示在阿尔茨海默病（AD）脑正电子发射断层扫描（PET）中的诊断效用。

材料与方法

对39例可能患有AD的患者（年龄53 - 82岁；男性15例，女性24例）和40例无AD的受试者（年龄21 - 78岁；男性14例，女性26例）在静脉注射2 - 脱氧 - 2 - [氟 - 18]氟 - D - 葡萄糖后获得的标准横轴位断层图像和3D - SSP PET图像集进行随机解读。进行了受试者操作特征（ROC）分析。

结果

3D SSP的诊断性能更优（Az[断层]=0.94，Az[3D SSP]=0.99[Az = ROC曲线下面积]；P = 0.043）。使用3D SSP时，初学者和专家对AD的诊断效果相当。在可疑或轻度痴呆患者中，3D SSP的敏感性和特异性分别为94%和99%，标准横轴位显示的敏感性和特异性分别为79%和88%。