Burdette J H, Minoshima S, Vander Borght T, Tran D D, Kuhl D E
Department of Radiology, University of Michigan Medical Center, University Hospital, Ann Arbor 48109-0028, USA.
Radiology. 1996 Mar;198(3):837-43. doi: 10.1148/radiology.198.3.8628880.
To compare the diagnostic usefulness of three-dimensional (3D) stereotaxic surface projection (SSP) with that of standard transaxial display in brain positron emission tomography (PET) in Alzheimer disease (AD).
Standard transaxial section display and 3D-SSP PET image sets obtained after administration of 2-deoxy-2-[fluorine-18]fluoro-D-glucose in 39 patients with probable AD (aged 53-82 years; 15 men, 24 women) and 40 subjects without AD (aged 21-78 years; 14 men, 26 women) were randomly interpreted. Receiver operating characteristic (ROC) analysis was performed.
Diagnostic performance was superior with 3D SSP (Az[section]=0.94,Az[3D SSP]=0.99[Az=area under the ROC curve];P=.043). With 3D SSP, diagnosis of AD was equally good in beginners and experts. The sensitivity and specificity in questionable or mild dementia were 94% and 99% with 3D SSP and 79% and 88% with standard transaxial display.
Accuracy of detecting AD was improved in PET with 3D SSP.
比较三维（3D）立体定向表面投影（SSP）与标准横轴位显示在阿尔茨海默病（AD）脑正电子发射断层扫描（PET）中的诊断效用。
对39例可能患有AD的患者（年龄53 - 82岁；男性15例，女性24例）和40例无AD的受试者（年龄21 - 78岁；男性14例，女性26例）在静脉注射2 - 脱氧 - 2 - [氟 - 18]氟 - D - 葡萄糖后获得的标准横轴位断层图像和3D - SSP PET图像集进行随机解读。进行了受试者操作特征（ROC）分析。
3D SSP的诊断性能更优（Az[断层]=0.94，Az[3D SSP]=0.99[Az = ROC曲线下面积]；P = 0.043）。使用3D SSP时，初学者和专家对AD的诊断效果相当。在可疑或轻度痴呆患者中，3D SSP的敏感性和特异性分别为94%和99%，标准横轴位显示的敏感性和特异性分别为79%和88%。
PET采用3D SSP可提高AD的检测准确性。
