Garside D A, Charlton A, Heath K J
Medicines Safety Evaluation Division, Glaxo-Wellcome Research and Development, Hertfordshire, United Kingdom.
Regul Toxicol Pharmacol. 1996 Feb;23(1 Pt 1):69-73. doi: 10.1006/rtph.1996.0010.
The purpose of this study was to establish the timing of the onset of implantation in both the Harlan Porcellus Dutch and New Zealand White rabbit and the Han Wistar rat. Implantation was initiated on Day 5 (rat) and 7 (rabbit) and established by Day 7 and 8 of gestation in the rat and rabbit, respectively. Recent guidelines on toxicity testing during embryo-fetal development studies require that maternal exposure to pharmaceutical compounds does not occur until after implantation has taken place. In order to ensure that this is the case, female Harlan Porcellus Dutch and New Zealand White rabbits and Han Wistar rats were sacrificed on different days of gestation, over the expected periods of implantation. The presence of preimplantation blastocysts in the uterus was investigated, and evidence of established implantation sites was assessed.
本研究的目的是确定哈兰·波塞勒斯荷兰兔和新西兰白兔以及汉·威斯塔大鼠着床开始的时间。大鼠在妊娠第5天开始着床，兔子在妊娠第7天开始着床，大鼠和兔子分别在妊娠第7天和第8天确立着床。胚胎-胎儿发育研究中近期的毒性测试指南要求，母体直到着床发生后才接触药物化合物。为确保情况如此，在预期的着床期内，在不同妊娠天数处死雌性哈兰·波塞勒斯荷兰兔、新西兰白兔和汉·威斯塔大鼠。研究子宫中着床前胚泡的存在情况，并评估已确立着床部位的证据。
