Patrick T B, Bresee R R
J Pharm Sci. 1976 Jul;65(7):1066-7. doi: 10.1002/jps.2600650729.
The enthalpy of hydrogen bonding of some antipsychotic, antidepressant, anticonvulsant, and antianxiety agents with phenol, as determined from IR and NMR spectroscopic measurements, was shown not to be responsible for differences in activity within the drug classes. These results support a theoretical prediction advanced for anticonvulsant activity.
通过红外光谱和核磁共振光谱测量所确定的一些抗精神病药、抗抑郁药、抗惊厥药和抗焦虑药与苯酚形成氢键的焓,并未显示出与药物类别内活性差异有关。这些结果支持了针对抗惊厥活性提出的理论预测。