体外受精程序后未受精卵母细胞的染色体分析：初步报告。

Chromosome analysis of unfertilized oocytes after in vitro fertilization program: a preliminary report.

作者信息

Makemaharn O, Srivannaboon S

机构信息

Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 1995;26 Suppl 1:96-9.

PMID:8629151

Abstract

To assess the contribution of chromosome anomalies to high failure of in vitro fertilization (IVF), a total of sixty three eggs from 37 women participating in the IVF program were cytogenetically investigated. The mean age of the oocytes donors was 36.8 years. Chromosome karyotype was obtained in 30 of unfertilized oocytes: 16 oocytes (53.3%) had a normal haploid chromosome complement; 5 (16.7%) were hypohaploid; 3 (10.0%) were hyperhaploid; 3 (10.0%) were diploid, 3 (10.0%) were polyploid. It may explain for early pregnancy loss, low pregnancy rate after in vitro fertilization.

摘要

为评估染色体异常对体外受精（IVF）高失败率的影响，对参与IVF项目的37名女性的63枚卵子进行了细胞遗传学研究。卵母细胞供体的平均年龄为36.8岁。对30枚未受精的卵母细胞进行了染色体核型分析：16枚卵母细胞（53.3%）具有正常的单倍体染色体组成；5枚（16.7%）为亚单倍体；3枚（10.0%）为超单倍体；3枚（10.0%）为二倍体，3枚（10.0%）为多倍体。这可能解释了早期妊娠丢失以及体外受精后妊娠率低的原因。