Urasiński I, Zdziarska B, Krygier-Stojałowska A
Kliniki Hematologii Instytutu Chorób Wewnetrznych.
Acta Haematol Pol. 1996;27(1):49-55.
Bone marrow abnormalities were assessed in 6 patients with hairy cell leukemia after 2-chlorodeoxyadenosine treatment. In spite of clinical and haematological remission in all patients, hairy cells and fibrosis were found within the marrow. However, the hairy cells number, the thickness of argentophilic fibres and the extent of fibrosis. It was stressed that in addition to histological analysis with hematoxylin-eosin also other stainings for fibrosis should be applied in the bone marrow evaluation, followed by immunohistochemical and molecular methods which allow to exclude minimal residual disease after leukemia treatment.
对6例毛细胞白血病患者接受2-氯脱氧腺苷治疗后的骨髓异常情况进行了评估。尽管所有患者均实现了临床和血液学缓解，但在骨髓中仍发现了毛细胞和纤维化。然而，毛细胞数量、嗜银纤维厚度和纤维化程度各异。强调在骨髓评估中，除苏木精-伊红组织学分析外，还应采用其他纤维化染色方法，随后进行免疫组织化学和分子方法检测，以排除白血病治疗后的微小残留病。
