82例卵巢功能衰竭患者的表型和细胞遗传学发现——变化趋势

Phenotypic and cytogenetic findings in eighty-two patients with ovarian failure--changing trends.

作者信息

McDonough P G, Byrd J R, Tho P T, Mahesh V B

出版信息

Fertil Steril. 1977 Jun;28(6):638-41. doi: 10.1016/s0015-0282(16)42615-4.

Abstract

Eighty-two patients with primary ovarian failure were evaluated clinically and cytogenetically. Sex chromosome privations were present in 52 individuals (chromosomally incompetent ovarian failure [CIOF]). A normal chromosomal constitution was present in 30 individuals (chromosomally competent ovarian failure [CCOF]). Limited estrogenic function (menses) occurred in 11.5% of the CIOF group and 40% of the CCOF group. The phenotypic features of each group are detailed in relation to chromosomal constitution, stature, estrogenic ridge function, incidence of dysgenetic tumors, and cardiovascular renal malformations. The increasing percentage of patients with CCOF due to possible diverse etiologies is noted and discussed.

摘要

对82例原发性卵巢功能衰竭患者进行了临床和细胞遗传学评估。52例个体存在性染色体缺失（染色体功能不全性卵巢功能衰竭[CIOF]）。30例个体染色体构成正常（染色体功能正常性卵巢功能衰竭[CCOF]）。CIOF组11.5%、CCOF组40%出现有限的雌激素功能（月经）。详细阐述了每组的表型特征，涉及染色体构成、身高、雌激素嵴功能、发育异常肿瘤的发生率以及心血管肾脏畸形。注意到并讨论了因可能的多种病因导致CCOF患者比例的增加。