Kaczorowski J M, Wax P M
Department of Pediatrics, University of Rochester School of Medicine, New York, USA.
Ann Emerg Med. 1996 Feb;27(2):258-63. doi: 10.1016/s0196-0644(96)70334-7.
The maximum duration and volume of polyethylene glycol electrolyte solution (PEG-ELS) that can be safely administered during whole-bowel irrigation of the poisoned patient are poorly defined. We present a case of a 33-month-old boy who ingested at least 160 mg/kg elemental iron and received 44.3 L of PEG-ELS (2,953 ml/kg) over 5 days because of the persistence of iron tablets in teh gastrointestinal tract. The child remained clinically well after initiation of PEG-ELS therapy, and further significant iron absorption did not appear to occur. The rectal effluent cleared within 2 days of the start of PEG-ELS therapy despite the persistence of iron in the gastrointestinal tract as shown on radiography. No adverse effects resulted from teh large volume or duration of the PEG-ELS therapy. This is the greatest reported volume of PEG-ELS to be used for whole-bowel irrigation in the treatment of a toxic ingestion.
在对中毒患者进行全肠道灌洗时，聚乙二醇电解质溶液（PEG - ELS）能够安全使用的最大时长和剂量尚无明确定义。我们报告了一例33个月大的男孩，他摄入了至少160mg/kg的元素铁，由于胃肠道内持续存在铁剂，在5天内接受了44.3L的PEG - ELS（2953ml/kg）。在开始PEG - ELS治疗后，患儿临床状况良好，且未出现进一步显著的铁吸收。尽管X线检查显示胃肠道内仍有铁剂，但在开始PEG - ELS治疗2天内直肠排出物就已清除。PEG - ELS治疗的大容量或长时间并未产生不良反应。这是治疗中毒性摄入时全肠道灌洗所使用的PEG - ELS报告的最大剂量。
