Honda A, Nishimura S
Banyu Tsukuba Research Institute, Merck Research Laboratories, Ibarakgi, Japan.
Biochem Biophys Res Commun. 1996 Apr 25;221(3):602-8. doi: 10.1006/bbrc.1996.0642.
Retroviruses employ translation frameshift for gene expression. Translation frameshift takes place at the slippery heptanucleotide sequence on mRNA. A downstream stem-loop structure (and a pseudoknot formed by the stem-loop) enhances the level of ribosomal frameshifting. Here, we describe that an upstream termination codon suppresses the ribosomal frameshifting, leading to reduction in the expression of downstream genes.
逆转录病毒利用翻译移码进行基因表达。翻译移码发生在mRNA上的七核苷酸滑动序列处。下游的茎环结构（以及由该茎环形成的假结）会提高核糖体移码的水平。在此，我们描述了一个上游终止密码子会抑制核糖体移码，从而导致下游基因表达减少。
