Adhya T K, Apte S K, Raghu K, Sethunathan N, Murthy N B
Division of Soil Science and Microbiology, Central Rice Research Institute, Cuttack, India.
Biochem Biophys Res Commun. 1996 Apr 25;221(3):755-61. doi: 10.1006/bbrc.1996.0669.
When exposed to the potent insecticide gamma-hexachlorocyclohexane or lindane, a Sphingomonas paucimobilis strain rapidly synthesized 7 novel polypeptides and concomitantly gained the ability to degrade lindane. Synthesis of these proteins was switched-off subsequent to the disappearance of lindane from the medium. Treatments which induced the synthesis of identical proteins also conferred on cells the ability to degrade lindane. In contrast, cells blocked in protein synthesis could not be induced to degrade lindane. The close correspondence observed between expression of lindane-induced proteins and gamma-hexachlorocyclohexane catabolism strongly implicates these novel proteins in lindane biodegradation.
当暴露于强效杀虫剂γ-六氯环己烷（林丹）时，少动鞘氨醇单胞菌菌株会迅速合成7种新的多肽，并同时获得降解林丹的能力。这些蛋白质的合成在林丹从培养基中消失后停止。诱导相同蛋白质合成的处理也赋予细胞降解林丹的能力。相比之下，蛋白质合成受阻的细胞不能被诱导降解林丹。林丹诱导蛋白的表达与γ-六氯环己烷分解代谢之间的密切对应强烈表明这些新蛋白质参与林丹的生物降解。
