[Initial prospective evaluation of cancer incidence in relation to metabolism of antipyrine and family history in patients with lung cancer].

Our previous studies revealed faster antipyrine metabolism among lung cancer patients and their first degree relatives in comparison with subjects without cancer history in their families. After 8 years 39-70% previously investigated first degree relatives of lung cancer patients and 55-73% previously investigated healthy subjects without cancer in their families were examined. One lung cancer case was noticed in the group of relatives and this subjects had very fast antipyrine metabolism. Also 2 cases of non-smoking related cancer were observed in subjects with intermediate antipyrine metabolism. Only one case of non-smoking related cancer was noticed among controls and this subjects had rather slow antipyrine metabolism.